Cannabielsoin was first discovered in 1983 by Ohio State University Researchers. Cannabidiol is formed from cannabielsoin through the metabolic process that makes it a metabolite.

Researchers at the Hokuriku University – Japan picked interest in the compound due to their interest in the biological mechanism resulting in its formation.

It has already been known that CBL is a product of degradation. Its formation is as a result of contact of the cannabis plant with light. Both compounds are classified as cannabinoids.

Currently, no pharmacological property has been identified in cannabielsoin and CBL. However, what must be known and understood is the process through which CBE is formed in the human body or in the cannabis plant.

What Does the Research Say About Cannabielsoin?

Cannabielsoin has been discovered in suspension cultures of Saccharum officinarum and Cannabis sativa under optimum growth conditions.  The compound has also been discovered in the liver of the guinea pig who received an intraperitoneal administration of cannabidiol an hour earlier. Cannabielsoin has little to no effect on the temperature of the body and pentobarbital-induced sleep.

Cannabielsoin does not have psychoactive properties though it is derived from CBD.

Comparing Cannabielsoin with Cannabicyclol

Cannabicyclol does not have psychomimetic properties hence it doesn’t induce euphoria or hallucinations – effects caused by tetrahydrocannabinol and other cannabinoids with psychoactive properties.

A 1983 study] used gas chromatography and mass spectrometry to analyze CBD metabolites. It was discovered that cannabidiol gave rise to cannabielsoin as a new metabolite.  

Compound Type

  • Aromatic Hydrocarbon
  • Dibenzofuran
  • Ether
  • Industrial By-product/Pollutant
  • Industrial/Workplace Toxin
  • Lachrymator
  • Organic Compound
  • Pesticide
  • Pollutant
  • Synthetic Compound

The benefits of this compound and its interaction with other cannabinoids are yet to be discovered due to lack of research.


Yamamoto, H. Gohda, S. Narimatsu, H. Yoshimura: Identification of cannabielsoin, a novel metabolite of cannabidiol formed by guinea-pig hepatic microsomal enzymes, and its pharmacological activity in mice. In: J Pharmacobiodyn. December 1988,

Hartel et al. Biotransformation of Cannabidiol to Cannabielsoin by Suspension Cultures of Cannabis sativa and Saccharum officinarum. Planta Med (48)1: 7-9. May 1983.


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